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Evidence is increasing that every addiction without exception is related to difficulty with the brain's reward center, specially the mesolimbic system. This part of the problem regulates reward responses in getting food and sex, plus in nurturing infants and children. One of the most important neurotransmitters involved with reward responses, both when they malfunction and once they function properly, is dopamine. What makes opiates unique is that it, among other neurotransmitters modulates "the quantity of dopamine released in responding to a stimulus"(Bostwick & Bucci, 2008).

Using two separate drugs to shed weight can be very effective there are combinations while watching FDA now awaiting approval. When dealing with weight-loss and the those who go through it you need to err to the side of caution and let the FDA do its job and demand some study be done so that the public is aware of the side effects and dangers of the medications before we drive them. Keep in mind that drug companies come in business to generate money and that they would say everything to keep people on their medications.

Researchers discovered that participants taking this drug for any year, lost weight within four weeks and have kept the body weight off through the entire 56 weeks with the study. Contrave is often a combination of the drugs naltrexone and bupropion, which usually reflect a brand new trend of weight-loss drugs which might be made up of more than one active ingredient, which may make them more effective and safer.

Combo-pilling could be the newest fad or in addition to this the newest to come under scrutiny and thus it is just more publicly known lately, comb-pilling for losing weight has been around since the eighties. The biggest reason that by using a combination of pills is starting to become popular is the fact that as of right now there aren't long term prescription slimming capsules that have been licensed by the FDA apart from orlistat. The truly disturbing part is the fact that doctors are prescribing these combinations of medications even though some of the combinations are already rejected or have yet to be licensed by the FDA.

Seizures can be a side effect with Contrave and really should not be taken in those with seizure disorders. The drug also can raise blood pressure level and heartbeat, and must not be used in people with a history of cardiac event or stroke in the earlier six months. Blood pressure and pulse should also be measured before starting the drug and throughout therapy while using drug.

The FDA also warned that Contrave can raise hypertension and pulse rate and must not be used in patients with uncontrolled high hypertension, and also by anyone with heart-related and cerebrovascular (circulatory dysfunction impacting mental performance) disease. Patients having a history of heart attack or stroke in the earlier six months, life-threatening arrhythmias, or congestive heart failure were excluded from your clinical trials. Those taking Contrave really should have their heart-rate and pulse monitored regularly. In addition, since compound includes bupropion, Contrave comes which has a boxed warning to alert medical researchers and patients on the increased likelihood of suicidal thoughts and behaviors linked to antidepressant drugs. The warning also notes that serious neuropsychiatric events are already reported in patients taking bupropion for stop smoking.

--Participating in support groups that really help the family from the addict recover (like Al-Anon or Nar-Anon).

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